Radiomics in PET/CT: More Than Meets the Eye?

In the present issue of the J Nucl Med, Orlhac and colleagues present a study comparing visual assessment of uptake heterogeneity in positron emission tomography (PET) images by experts and a subset of radiomics metrics, namely textural features (TF). They exploited both clinical and simple simulated PET images, going further than previous studies carried out using clinical data only (4–6). Such studies are useful because they provide additional understanding relative to the visual meaning of quantitative metrics that cannot be easily explained to non‐specialists. These studies have focused on the PET component and the FDG uptake heterogeneity. Similar analyses have been carried out in computed tomography (CT) (7) or magnetic resonance imaging (MRI) (8).